Reserve one of our hotels in Panama City, home to the famous Panama Canal as well as some of the region's most noteworthy colonial-era landmarks.

Panama City Hotels

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Panama City Panama, PA
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Showing 1-16 of 16 hotels
Calle 56 y 57, Obarrio Panama City, Panama
0.3 miles from destination
Why Autograph Collection
Independent Hotels | Distinctive Design | Unique Experiences
Why Autograph Collection
Via Espana & Ricardo Arias Street Panama, Panama 05890-823
0.4 miles from destination

Opening Soon Jul 2024

Why Renaissance Hotels
Neighborhood Discoveries | Intriguing Design | Evening Bar Scene
Why Renaissance Hotels

Opening Soon Jul 2024

Calle Ricardo Arias 14, Campo Alegre Area Bancaria Panama City, Panama
0.4 miles from destination
Hotel in downtown Panama City, Panama, with complimentary Wi-Fi, stylish décor and rooftop pool.
Why AC Hotels
Intuitive Service | Thoughtful Design | European-Inspired Breakfast
Why AC Hotels
Calle 50 and Aquilino de la Guardia Panama City, Panama 80809
0.4 miles from destination
Wow-worthy hotel with pet-friendly lodging in the heart of Panama City, near Cinta Costera.
Why W Hotels
Bold Design | Whatever/Whenever Service | Always Activated
Why W Hotels
Multiplaza Pacific Mall, Via Israel Avenue Panama City, Panama
0.5 miles from destination
Downtown Panama City, Panama hotel with pet-friendly rooms, four event rooms and a restaurant.
Why Courtyard
Full Bar & Made-To-Order Breakfast/Dinner | Free Wi-Fi | 24/7 Markets
Why Courtyard
Calle Uruguay & Balboa Avenue Panama City, Panama
0.6 miles from destination
Located near restaurants, entertainment and corporate offices, in front of the Panama Bay.
Why Le Méridien
Chic Design | Illy coffee | Sparkling Cocktails | European Heritage
Why Le Méridien
Recently Renovated
Marriott Executive Apartments Panama City, Finisterre
Marriott Executive Apartments Panama City, Finisterre
Calle Colombia & Calle Republica del Paraguay Panama City, Panama
0.7 miles from destination
An extended-stay hotel in Panama City with complimentary Wi-Fi and apartment-style lodging.
Why Marriott Executive Apartments
Elevated Serviced Apartments | Full Kitchens | 24/7 Security
Why Marriott Executive Apartments
Calle Ramon H Jurado, Calle Tomas Gabriel Duque, Edificio Pacific Center Panama City, Panama
0.7 miles from destination
Strategic location near Costa del Este. Spacious rooms with equipped kitchens ensure comfort.
Why Residence Inn
Suites with Full Kitchens | Outdoor Living Spaces | Free Hot Breakfast
Why Residence Inn
Calle Punta Colon, Punta Pacifica, Corregimiento de San Francisco Panama City, Panama 0833-00118
1.0 miles from destination
Luxury hotel in Panama City, Panama with infinity pool, on-site dining and pet-friendly rooms.
Why JW Marriott
Serene luxury | Intuitive service | Regional-inspired cuisine
Why JW Marriott
Via Israel & Calle 76, San Francisco Panama City, Panama 0819-05896
1.3 miles from destination
A bold new hotel featuring loft-inspired design. Work and play in our modern and full service hotel
Why Aloft Hotels
Vibrant Communal Spaces | Music Moments | W XYZ bar
Why Aloft Hotels
Vía Israel y Calle 77, San Francisco Panama City, Panama 0819-05896
1.3 miles from destination
Waterfront hotel with luxury rooms and suites near Tocumen International Airport and Panama Viejo.
Why Sheraton
Welcoming Service | Flexible Spaces to Meet, Work & Relax
Why Sheraton
Albrook Mall, Roosevelt Avenue Panama City, Panama
2.4 miles from destination
Stay connected to the best experiences in town at our Albrook hotel in Panama City
Why Marriott Hotels & Resorts
Trusted Service | Modern Guestrooms | M Club (select hotels)
Why Marriott Hotels & Resorts
La Rotonda Avenue, Costa del Este Panama City, Panama
3.6 miles from destination
Hotel is strategically located in the upscale trendy neighborhood of Costa del Este
Why Westin Hotels & Resorts
Wellness Offerings | Heavenly Bed | Eat Well Menu | WestinWORKOUT
Why Westin Hotels & Resorts
Santa Maria Boulevard Panama City, Panama
5.6 miles from destination
Five-star hotel in Panama City, Panama with Panamanian cuisine, a spa and exclusive meeting venues.
Why The Luxury Collection
Storied Hotels | Destination Discoveries | Epicurean Moments
Why The Luxury Collection
Avenida Domingo Diaz via Tocumen, Centro Comercial MetroMall Panama City, Panama
6.9 miles from destination
Pet-friendly lodging near the Metromall in Panama City with free parking and Wi-Fi and a restaurant.
Why Courtyard
Full Bar & Made-To-Order Breakfast/Dinner | Free Wi-Fi | 24/7 Markets
Why Courtyard
Km 6 Camino a Veracruz Panama City, Panama
6.9 miles from destination
Oceanfront resort with all-inclusive packages and a spa near Veracruz Beach and Biomuseo.
Why Westin Hotels & Resorts
Wellness Offerings | Heavenly Bed | Eat Well Menu | WestinWORKOUT
Why Westin Hotels & Resorts

Panama City

Panama City is the capital of Panama, located on the southern tip of North America. One of the most famous Panama City attractions is the Panama Canal, where visitors can watch the ships at the Miraflores Locks Visitor Center. Another popular place to explore is the Casco Viejo, or the Old Quarter, with historic buildings and lovely colonial architecture. Here, guests staying in Panama City hotels will find Las Bóvedas and Plaza de Francia, the president’s home Palacio de las Garzas, and the Panama Canal Museum. For a little more history, head to the Panama Viejo ruins, a site that was once destroyed by pirates. Thanks to its tropical climate, there are many things to do in Panama City that are outdoors. Hike up the Ancon Hills or explore the Parque Natural Metropolitano for a stunning view of the city’s skyline. Another option is to stroll by the ocean on the Cinta Costera, a city boardwalk, or at the Causeway. Here, visitors will also find the Biomuseo, a stunning structure by Frank Gehry and a museum of life sciences. For dinner, head back to Casco Viejo for top restaurants or grab local food at the fish market located right by the ocean.